Considering a child’s end of life may feel like an impossible prospect, but many parents and other close caregivers do address this possibility as early as the initial diagnosis of a potentially life-threatening illness. While hope is always a part of the care plan, that hope can change shape as a child’s condition and/or prognosis shifts. There are obviously no guarantees that things will happen in a predictable fashion. The goal is to benefit from insights and practical information that shines a light on the unimaginable and unknown. Hopefully this will lessen the dread that loved ones hold in their heads and hearts.